FDA Issues Second Warning Against Treating Leg Cramps With Quinine

Medscape/Robert Lowes/July 8, 2010 — Physicians should not prescribe the malaria drug quinine (Qualaquin) for nocturnal leg cramps — an off-label use — because it may result in serious and life-threatening hematologic adverse effects, the US Food and Drug Administration (FDA) announced today.

The FDA issued a similar warning in 2006 but the agency noted today that the majority of quinine used in the United States is still for the prevention of leg cramps.

Quinine therapy may result in thrombocytopenia, which can cause serious bleeding or hemolytic-uremic-syndrome/thrombotic thrombocytopenic purpura, which may lead to permanent kidney damage.

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One Response to “FDA Issues Second Warning Against Treating Leg Cramps With Quinine”

  1. Anthony Dumont Says:

    Nighttime leg cramps are different from another common nighttime leg problem called restless legs syndrome. ;`:`:

    Enjoy your weekend! http://healthmedicinelab.com/citalopram-side-effects/

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